Pharmacokinetics of Baytril^® 

Effective antimicrobial therapy depends on a triad of the dosage regimen, bacterial susceptibility and pharmacokinetic characteristics.

The pharmacokinetic parameters give an overview on the achievable concentrations (which depend on the systemic availability of the drug, which varies with the drug preparation, the route of administration and the dosing rate).

The unique formulations of Baytril® provide high serum concentrations as well as excellent bioavailability and tissue penetration.

Because the efficacy of fluoroquinolones is concentration-dependent, high values for Cmax, AUC and AUIC are important.

Cmax is defined as the maximum serum concentration obtained after application.

AUC is the area under the plasma concentration-time curve. When comparison is made between an oral dosage form with that of an i.v. preparation of the drug, the absolute bioavailability (systemic availability) is obtained. The comparison between two AUCs for two dosage forms (test and reference) allows bioequivalence assessment. A lack of efficacy can be predicted in products that are found not to be bioequivalent to the standard formulation.