Baytril^® in Serum and Tissues

Baytril's outstanding pharmacokinetic properties are clearly shown by the achievable tissue concentrations.

After a single dose of 2.5 mg Enrofloxacin/kg, the following concentrations in µg/ml (µg/g) can be achieved in cattle:

route	serum	lungs	liver	muscle	bone	kidney	jejenum wall	milk
i.v.	2.65	1.20	8.20	1.31	0.61	5.7	1.18	5.30
s.c.	0.67	1.09	2.0	0.98	0.45	2.25	1.18	2.0
i.m.	0.83	1.15	2.5	0.91	0.74	2.41	1.2	1.7

(data on file)

These data are more informative when linked to the susceptibility of relevant pathogens.

The serum kinetics show the increase in concentrations when doubling the dose (2.5 mg Enrofloxacin/kg vs. 5.0 mg/kg s.c.), which also leads to a linear increase of tissue concentrations.

The serum and tissue concentrations that can be reached with Baytril® will always be higher than the MIC values of the important pathogens that are covered by Baytril's spectrum of activity.